J. Anim Sci.
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J. Anim Sci. 1975. 40:911-916.
© 1975 American Society of Animal Science
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Somatostatin: Its Influence on Plasma Levels of Growth Hormone, Prolactin and Thyrotropin in Sheep

S. L. Davis1

University of Idaho,2, Moscow 83843

Abstract

The influence of synthetic somatostatin (somatotropin-release-inhibiting factor, SRIF) on ovine growth hormone (oGH), prolactin (oPRL) and thyrotropin (oTSH) secretion was studied in eight immature ewe lambs (26 to 36 kg). In the first experiment, SRIF treatment was combined with an arginine infusion. The second study was conducted to examine the effect of SRIF on basal levels of oGH, oPRL and oTSH. The third study involved treatment with SRIF + thyrotropin-releasing hormone (TRH) as compared to TRH alone.

The infusion of arginine resulted in a significant (P < .05) increase in plasma levels of oGH. SRIF treatment significantly (P <.05) decreased the oGH response to arginine. The oPRL response to arginine was present, but not significant because of wide between animal variability. SRIF treatment had no significant influence on plasma oTSH, or the oPRL response to arginine.

The continuous infusion of SRIF for 1 hr had no significant (P < .05) effect on basal plasma levels of oGH, oPRL or oTSH.

Footnotes

1 The author would like to thank Mr. Dan Ohlson and Mrs. Jan Miller for technical assistance; Dr. L. E. Reichert, Dr. A. E. Wilhelmi and Dr. J. G. Pierce for supplying the purified oPRL, oGH and bTSH used for radioiodination; and the National Institutes for Health for supplies of oGH, oPRL and oTSH reference standards. Additionally, the author is grateful to Dr. R. Guillemin for providing synthetic somatostatin and Dr. R. G. Sasser and Dr. Rodney Mead for reviewing the manuscript.

2 Department of Animal Industries.






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