J. Anim Sci.
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J. Anim Sci. 1975. 40:844-850.
© 1975 American Society of Animal Science
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Effects of Single Intramuscular Injections of Selenium at Various Levels to Young Swine1, 2,

J. S. Diehl3, D. C. Mahan4 and A. L. Moxon4

The Ohio State University, Columbus 43210 and Ohio Agricultural Research and Development Center, Wooster, 44691

Abstract

An experiment involving 33 pigs initially weighing 18 kg, was conducted to investigate the effects of a single intramuscular injection of selenium (sodium selenite) at different levels on resulting blood and tissue selenium concentrations at various time intervals post-injection and to determine the effect of a single lethal injectable dosage of selenium.

Five pigs were allotted to each of the first four and three pigs to each of the remaining ensuing treatments: Control (no injection), .275, .55, 1.10, 1.65, 2.20, 2.75 and 3.30 mg Se/kg body weight (BW). Serum samples were collected by cardiac puncture prior to treatment injections and during eight additional collection periods from 12 hr to 50 days post-injection. Serum was analyzed for SGOT and selenium. One pig was sacrificed initially as were two and three pigs from each of the surviving treatment groups at 24 and 60 days post-injection, respectively, from which hepatic, kidney and longissimus muscle tissues were collected and analyzed for selenium. The same tissues were collected from those pigs dying of selenosis.

Footnotes

1 Approved for publication as Journal Article No. 63-74 by the Director of the Ohio Agricultural Research and Development Center, Wooster.

2 Appreciation is expressed to Larry Mangan and Orlin Reed for their aid in the collection of data, blood and tissue samples, and to Dr. L. A. Swiger for his help with the statistical analyses.

3 Department of Animal Science, The Ohio State University, Columbus.

4 Department of Animal Science, The Ohio Agricultural Research and Development Center, Wooster.






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Copyright © 1975 by the American Society of Animal Science.