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Anthelmintic Activity of Levamisole against Ascaris, Trichuris and Metastrongylus Infection in Swine¹

University of Nebraska, Lincoln 68503

Abstract

Two groups of five pigs, naturally infected with Ascaris suum and Trichuris suis and experimentally infected with Metastrongylus spp., were treated with levamisole at a rate of 8 mg per kilogram of body weight at 35 days post-infection with lungworm larvae. When administered in the feed, the anthelmintic efficacy was 99.6% for lungworms, and 100% for ascarids and whipworms. When levamisole was administered in the drinking water, efficacy was 99.5% for lungworms, 91% for whipworms, and 100% for ascarids. These counts were compared with one group of four infected, untreated controls on the basis of post-mortem worm counts.

¹ Published with the approval of the Director, as Paper No. 3491, Journal Series, Nebraska Agricultural Experiment Station.

² Veterinary Science Department.

³ University of Nebraska North Platte Station, North Platte.

⁴ d1–2, 3, 5, 6-tetrahydro-6-phenylomidazo(2, 1-b) thiazole hydrochloride.