J. Anim Sci.
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J. Anim Sci. 1975. 40:720-726.
© 1975 American Society of Animal Science
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203Hg Excretion and Tissue Distribution in Holstein Calves following Single Tracer Intravenous Doses of Methyl Mercury Chloride or Mercuric Chloride1

P. E. Stake, M. W. Neathery, W. J. Miller and R. P. Gentry

University of Georgia2 Athens 30602

Abstract

Eight male Holstein calves were given a single tracer intravenous dose of 203Hg as mercuric chloride or methyl mercury chloride 7 days before sacrifice. Total 7-day fecal and urinary 203Hg excretions were much higher (P < .01) from mercuric chloride dosing (28.3 and 8.1% of the dose) than from methyl mercury chloride (6.1 and .4% of the dose). Retention of 203Hg from mercuric chloride was 2–8 times greater (P < .01) in kidney, liver, spleen, lung, testicle, rib shaft, tibia joint, tibia shaft, abomasum, small intestine, cecum and large intestine and higher (P < .05) in pancreas. In contrast, 203Hg from mercuric chloride was lower (P < .01) in brain cerebellum and cerebrum, supraspinatus muscle and heart, and substantially lower (P < .05) in psoas and semitendinosus muscles. Fifteen minutes after dosing, whole blood 203Hg was lower (P < .01) from mercuric chloride followed by a similar rapid clearance for both 203Hg forms. Throughout the 7-day period, plasma 203Hg was greater (P < .01) from mercuric chloride. In red blood cells, 203Hg from methyl mercury chloride was higher (P < .01) during the first 2 hr after dosing, with no significant differences thereafter.

Footnotes

1 Supported in part by Public Health Service Research Grant AM-O7367-NTN from the National Institute of Arthritis and Metabolic Diseases.

2 Department of Animal and Dairy Science.






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Copyright © 1975 by the American Society of Animal Science.