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Metabolic Fate of Diethylstilbestrol Implanted in the Ear of Steers

U. S. Department of Agriculture, Fargo, North Dakota 58102

Abstract

Four steers were implanted in the ear with approximately 28 mg of ¹⁴C-diethylstilbestrol (¹⁴C-DES) and were slaughtered 30, 60, 90 or 120 days later. All urine and feces were collected from time of implantation until slaughter. Total recoveries of ¹⁴C from excreta and tissues ranged from 82.7 to 90.9% of ¹⁴C implanted (avg 86.8%). The percentages of implanted ¹⁴C remaining in the ears were 65.9, 27.3, 30.0 and 4.2 at 30, 60, 90 and 120 days after implantation, respectively. Radioactivity was measurable in the plasma, urine and feces throughout the collection period for all steers.

Total excretions (urine and feces) were 34.7, 56.8, 52.5 and 84.9% of the ¹⁴C implanted for steers killed at 30, 60, 90 and 120 days, respectively. Approximately twice as much was excreted in feces as in urine. The concentrations of ¹⁴C were similar in the livers, kidneys, lungs and salivary glands of all steers. In the livers, 15 to 33% of the ¹⁴C present was characterized by isotopic dilution as ¹⁴C-DES or a conjugate of DES (.07 to .13 ppb DES equivalents).

¹ Agricultural Research Service, Metabolism and Radiation Research Laboratory, Fargo, North Dakota 58102

² Agricultural Research Service, Ruminant Nutrition Laboratory, Beltsville, Maryland 20705

³ The authors acknowledge the technical assistance of B. Lewton, A. Ortega, K. Mize, M. Bush and D. Cottrell. The advice and assistance of K. Davison is also acknowledged.

⁴ Reference to a company or product name does not imply approval or recommendation of the product by the U.S.D.A. to the exclusion of others that may be suitable.

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