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Effects of Prostaglandin F₂ on Estrous Cycle or Corpus Luteum in Mares and Gilts¹

University of Wisconsin, Madison 53706

Abstract

In Experiment 1, 20 pony mares were assigned by randomization to seven groups and six of the groups were injected subcutaneously (SC) with 1.25 mg prostaglandin F₂(PGF₂) on one of the following days of the estrous cycle (number of mares): 1(3), 4(3), 7(3), 10(3) or 13(2) post-ovulation or on day 2 of estrus (3). In Experiment 2, 24 pony mares were assigned by randomization to eight groups (three mares each) which were given an intramuscular (IM) or SC injection of one of the following doses of PFG₂; on day 7 post-ovulation: 0(controls), .25, .75 or 1.25 milligrams. In Experiment 3, three groups of three gilts each were injected IM on day 12 of the estrous cycle with one of the following doses of PGF₂: 0, 10 or 20 milligrams.

In Experiment 1, both estrus and ovulation appeared to be synchronized (mean intervals from treatment to estrus and ovulation were not significantly different) among mares given 1.25 mg PGF₂ SC on days 7, 10 or 13 post-ovulation, but not among mares given PGF₂ on days 1 or 4 post-ovulation or day 2 of estrus.

¹ From the Department of Veterinary Science, University of Wisconsin, Madison 53706. Supported by the College of Agricultural and Life Sciences, University of Wisconsin, Madison and by Grant No. 630-0505A from the Ford Foundation and by Public Health Service Training Grant No. 5-TO1- HD-00104-08. Experiments 1 and 2 (mares) were partially supported by a grant from National Association of Animal Breeders. Part of these data were presented at the 65th Annual Meeting of A.S.A.S. in Lincoln, Nebraska, July 29 to August 1, 1973. The prostaglandin F₂-tham salt was a gift from Dr. James Lauderdale, Upjohn Company, Kalamazoo, Michigan. The PGF₂, free acid was a gift from Dr. J. Black, Warner-Lambert Research Institute, Morris Plains, New Jersey.

² Predoctoral Trainee, Endocrinology-Reproductive Physiology Program, University of Wisconsin, Madison.