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Renal Response to Vasopressin Infusion in Vitamin A-Deficient and Normal Ewes¹

University of Kentucky, Lexington 40506

Abstract

Waterloaded normal and vitamin A-deficient crossbred ewes at maximum diuresis were infused in separate experiments with 1.5, 3.0 and 9.0 U/kg-min of arginine vasopressin. Urine volumes were measured every 10 min from the start of infusion until the preinfusion urine volumes were reached. Plasma samples were taken for electrolyte analysis at the start of infusion and at four subsequent 1O-min periods. Vitamin A-deficient ewes, given water ad libitum produced significantly more urine of a significantly lower osmolality than did normal ewes. However, under waterloaded conditions the A-deficient ewes excreted significantly less urine than normal ewes at maximum diuresis. Vasopressin infusion reduced urine excretion in normal ewes to a significantly greater extent than the A-deficient ewes at the 1.5 and 3.0 U levels of infusion. Urine osmolality was increased significantly in both A-deficient and normal ewes by ADH infusion. However, net change in urine osmolality was significantly higher in the normal ewes at the 1.5 and 3.0 U levels of infusion. Plasma osmolality was found to be significantly higher in vitamin A-deficient ewes at pre- and post-infusion for all levels of infusion. No significant differences were found between vitamin A-deficient and normal ewes with respect to plasma and urine sodium and potassium as a result of either level of ADH infusion. Data indicate that renal damage resulting from vitamin A deficiency also results in a reduced renal sensitivity to physiological levels of antidiuretic hormone.

¹ The investigation reported in this paper (No. 75-5-43) is in connection with a project of the Kentucky Agricultural Experiment Station and is published with the approval of the Director.

² Present address: Coastal Plain Station, Tifton, Georgia.