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Effect of Progesterone Induced Increase in Uterine Secretory Activity on Development of the Porcine Conceptus^{1, 2,}

University of Florida, Gainesville 32611

Abstract

Twelve crossbred gilts were randomly assigned to be either sham-operated or bilaterally ovariectomized on day 4 after onset of estrus and treated as follows: (1) sham-operated gilts received either corn oil alone (SO-CO) or 3.3 mg progesterone (P) and 0.55 ug estradiol (E)/kg/day (SO-HP) and (2) bilaterally ovariectomized gilts received either 1.1 mg P and 0.55 ug E/kg/day (OVX-LP) or 3.3 mg P and 0.55 ug E/kg/day (OVX-HP). These gilts were treated from day 4 to day 15 after onset of estrus when uterine flushings were obtained and total recoverable uterine protein determined. Total protein recovered was 87.7, 133.4, 86.1 and 133.5 mg for the SO-CO, SO-HP, OVX-LP and OVX-HP groups, respectively. The quantity of uterine protein recovered was significantly (P< .01) greater for the SO-HP and OVX-HP groups.

Thirteen contemporary gilts of the same age and weight were randomly assigned to the same treatments after breeding, and were also either sham-operated or bilaterally ovariectomized on day 4 after onset of estrus. However, in these gilts, treatment was carried out from day 4 to day 40 of gestation when the gilts were hysterectomized. There were no significant treatment effects on conception rate, number of corpora lutea, percent embryo survival, number of embryos or dry weight of the embryos. The SO-HP and OVX-HP treated gilts had significantly (P< .05) heavier empty uterine weight, greater allantoic fluid volume and longer placentae. Total allantoic fluid protein was not different in the SO-CO vs. SO-HP gilts, but was significantly (P< .01) greater in the OVX-HP vs. OVX-LP gilts. In general, progesterone therapy had no significant affect on embryonic survival or embryonic development, but it did affect development of the placentae and allantoic fluid volume at day 40 of pregnancy.

¹ Department of Animal Science, Florida Agricultural Experiment Station Journal Series No. 5244.

² This research was supported by U.S.D.A. Grant NO. 12-14-100-9962(44).

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