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Methionine, DL-Homocysteine Thiolactone and N-Acetyl-DL-Methionine for Ruminants¹

University of Kentucky⁴, Lexington 40506

Abstract

Plasma amino acid response of wethers to abomasal infusions of DL-methionine (DLM), DL-homocysteine thiolactone-HC1 (HCTL) and N-acetyl-DL-methionine (NAM), in vivo rumen stability of the latter two methionine analogs and preintestinal absorption of HCTL were studied. The daily infusion of 1.06 g of DLM elevated molar percentage of methionine and lysine in plasma and decreased molar percentage of threonine. Infusion of equal molar quantities of NAM and HCTL resulted in increased plasma methionine 1 hr. post-infusion. The oral administration of HCTL and NAM resulted in abomasal recoveries of only 10.5 and 15.7%, respectively; however, the methionine in abomasal fluid was significantly (P< .05) increased when HCTL was orally administered. Plasma methionine increased significantly following the intraruminal administration of HCTL to wethers with a ligated pyloric sphincter, but the intraruminal addition of methionine had no effect on plasma methionine.

¹ Supported in part by Smith Kline Animal Health Products, West Chester, Pa. 19380.

² Present Address: Richard B. Russell Agricultural Research Center, U.S.D.A., A.R.S., P.O. Box 5677, Athens, Ga. 30601.

³ College of Pharmacy.

⁴ Animal Sciences Department, Paper No. 73-5-113, Kentucky Agricultural Experiment Station.