J. Anim Sci.
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J. Anim Sci. 1974. 39:397-403.
© 1974 American Society of Animal Science
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Rate of Disappearance of Exogenous LH from the Blood in Mares1

O. J. Ginther, M. H. Pineda2, B. C. Wentworth and L. Nuti

University of Wisconsin, Madison 53706

Abstract

The disappearance rate in plasma of intravenously administered purified equine LH-131 I was studied in three anestrous mares. The calculated half-life of labeled LH was approximately 1 hr (58.9 ± 2.1 min.) during the first hour after injection and 4 to 5 hr. during the second and third hourly segments of the disappearance curve (261.8 ± 36.3 and 310.5 ± 14.2 min., respectively). The disappearance rate was significantly greater during the first hour than during the, next 2 hours. The disappearance rate for the second and third hours did not differ significantly. Similar disappearance rates were obtained in two additional experiments in which an equine pituitary fraction was given intravenously and the circulating levels of LH were determined by radioimmunoassay. The decrease in plasma LH was best characterized by a cubic regression line.

Footnotes

1 From the Departments of Veterinary Science and Poultry Science, University of Wisconsin, Madison 53706. Research supported by College of Agricultural and Life Sciences, University of Wisconsin, Madison and by grant No. 630-0505A from the Ford Foundation. The authors thank Dr. C. H. Del Campo for assistance in the collection of blood samples, Mr. W. Steffenhagen for assistance with data analysis and Dr. J. Lee for assistance with assays.

2 Postdoctoral Trainee, Endocrinology-Reproductive Physiology Program. Present address: Department of Physiology and Biophysics, School of Veterinary Medicine, Colorado State University, Fort Collins.






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Copyright © 1974 by the American Society of Animal Science.