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A Possible Mechanism for Induction of Porcine Malignant Hyperthermia Syndrome

Institute for Animal Husbandry "Schoonoord", Driebergseweg 10^d, Zeist, The Netherlands

Abstract

Isolated rat muscle mitochondria were subjected to varying concentrations of halothane (10–⁴ – 10–²M) and oxygen consumption was measured polarographically. State 3 respiratory rate was inhibited up to 60% at millimolar concentrations of halothane with glutamate and malate but not with succinate, as oxidizable subtrate; state 4 respiration during glutamate and malate oxidation was apparently not altered at this low concentration range. Elevated concentrations of halothane had opposite effects on state 4 respiration when glutamate and malate oxidation were compared to succinate oxidation. The relevance of these data to the aetiology of the porcine malignant hyperthermia syndrome (MHS) is discussed.

¹ The authors would like to thank Dr. S. G. van den Bergh for helpful discussion and Mrs. M. C. van der Lee for careful technical assistance.