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Intrauterine Administration of Prostaglandin F₂ in Cows: Progesterone, Estrogen, LH, Estrus and Ovulation¹

Michigan State University², East Lansing 48823

Abstract

In each of six Holstein cows, 5 mg PGF₂ (tham salt) was deposited in the uterine horn ipsilateral to the corpus luteum on day 11 of the estrous cycle. With intervening control estrous cycles between each PGF₂ treatment, the same cows were given 5 mg PGF₂ into the ipsilateral uterine horn on day 15 and on day 7 of the estrous cycle, and five of the six cows were given 5 mg PGF₂ into the contralateral uterine horn on day 11. The response of each endocrine or reproductive criterion was similar regardless of day of the cycle PGF₂ was administered or whether PGF₂ was deposited into the ipsilateral or contralateral uterine horn. After intrauterine PGF₂ treatment, 1) luteal diameter decreased (P<.01) from 2.5±.1 to 1.6±.1 cm within 24 hr., 2) serum progesterone fell (P<.01) from 3.6±.3 ng/ml to 1.7±.2, 1.2±.2 and 1.0±.1 ng/ml at 12, 24 and 48 hr., 3) serum estradiol increased (P<.01) from 5.0±1.0 pg/ml to 6.1±.4, 11.3±.7 and 12.7±1.3 pg/ml at 12, 24 and 48 hr., 4) a surge of LH occurred (P<01) with a peak at 71±4 hr., 5) standing estrus began at 72±5 hr. and 6) ovulation occurred at 95±5 hours. Based upon changes in blood serum LH, progesterone and estradiol and upon interestrual intervals, the estrous cycle which followed PGF₂, treatment did not differ significantly from control cycles in the same cows. In overview, exogenous PGF₂ caused dramatic luteolysis in cows, followed by increased estrogen secretion, an ovulatory surge of LH coincidental with onset of estrus, and ovulation. No residual influence of PGF² was detected on estrous cycles subsequent to PGF₂ treatment.

¹ Published with the approval of the Director of the Agricultural Experiment Station as Journal Article No. 6361; supported by USPHS Research Grant HD 06948.

² Department of Dairy Science.

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