HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Romans, J. R. Articles by Wahlstrom, R. C. Search for Related Content PubMed PubMed Citation Articles by Romans, J. R. Articles by Wahlstrom, R. C.

Preslaughter Treatment Affecting Intramuscular and Plasma Lipids I. Effect of ACTH in Rabbits¹

South Dakota Agricultural Experiment Station, Brookings 57006

Abstract

The effect of ACTH-induced stress on intramuscular and plasma lipids was studied in rabbits. Nine mature rabbits were subjected to a constant infusion of ACTH (1.5 mU/min./kg of body weight). A significant relationship existed between duration of ACTH infusion and the concentration of all plasma lipid classes. After 1 hr. of ACTH infusion, plasma free fatty acid (FFA) values were increased 11-fold over initial values. Following the initial peak, a slight decrease in FFA occurred during the ensuing treatment period. A significant (P<.01) quadratic relationship existed between time of ACTH infusion and plasma triglyceride (TG) levels. TG levels generally showed a slight decrease at 1 hr., and then gradually increased, culminating in a fourfold increase after 11 or 12 hours. Cholesteryl esters (CE) and cholesterol (C) responded significantly (P<.01) as quadratic expressions of time of ACTH infusion, CE decreasing with time and C showing a twofold increase from initial to final values. Phospholipids (PL) decreased in the first half of the treatment period but returned to initial levels by termination, a significant (P<.01) quadratic relationship. Total lipids (TL), the sum of the five classes, increased during treatment, resulting in a significant (P<.01) quadratic relationship with time of ACTH infusion. All classes of rabbit intramuscular lipids increased slightly during the stress period. When the six long-treatment rabbits (11 or 12 hr.) were considered separately, only the PL mean increase was significant (P<.05). Inclusion of data from the three short-treatment rabbits (2 to 6 hr.) resulted in significant (P<.05) mean increases in TG, C and TL.

¹ Published with the approval of the Director of the South Dakota Agricultural Experiment Station as Publication No. 1166a of the Journal Series.

² Present address: Department of Animal Science, University of Illinois, Urbana/Champaign 61801.

³ Department of Station Biochemistry.

⁴ Present address: U.S. Department of Agriculture, Animal Disease Laboratory, Ames, Iowa 50010.

⁵ Department of Animal Science.

⁶ Present address: Department of Animal Science, Kansas State University, Manhattan 66502.

⁷ The authors express gratitude to W. L. Tucker and H. W. Norton for aid in the statistical analysis.