HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Brooks, C. C. Articles by Miyahara, A. Y. Search for Related Content PubMed PubMed Citation Articles by Brooks, C. C. Articles by Miyahara, A. Y.

Effect of Menadione and Other Factors on Sugar-Induced Heart Lesions and Hemorrhagic Syndrome in the Pig^{1, 2,}

University of Hawaii, Honolulu

Abstract

Four trials with pigs and one trial with rats were conducted to determine the relationship of dietary sugar level, supplemental vitamin K, sodium salicylate, therapeutic levels of chlortetracycline and initial pig weight to development of sugar-induced heart lesions and hemorrhagic syndrome. The effects of crude vs. refined sucrose and glucose vs. sucrose were also compared. Each of the high sugar diets producedheart lesions and hemorrhagic syndrome in the pig. Vitamin K prevented both heart lesions and hemorrhagic syndrome in each of three trials with pigs. Rats did not develop heart lesions nor was hemorrhagic syndrome apparent from eating these same high sugar diets. Antibiotic prevented heart lesions but did not prevent the hemorrhagic syndrome nor lower prothrombin time in the pigs that were fed high sucrose diets. Diets containing either 63% glucose or 45% sucrose produced both conditions but to a lesser extent than did diets with 63% of either crude or refined sucrose. Lesions were more numerous and severity of lesions and hemorrhagic syndrome were greater when light pigs were started on high sugar diets. Both conditions occurred, however, among pigs that were started on test as heavy as 48 kilograms. Sodium salicylate did not prevent heart lesions or hemorrhagic syndrome.

¹ Journal Series No. 1587 of the Hawaii Agricultural Experiment Station.

² Menadione supplied gratis as menadione dimethylpyrimidinol bisulfite in a stabilized pre-mix under the trade name Hetrazeen by the Heterochemical Corporation, Valley Stream, New York.