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Alpha Chlorohydrin: Studies on the Mechanism of Action in Male Swine

U. S. Department of Agriculture^{1, 2, 3,}, Beltsville, Maryland 20705

Abstract

A study was made of the possible causes of infertility which results from feeding -chlorohydrin to boars. When gilts were inseminated via the oviducts, 37 of 54 ova recovered 2 days later from control gilts were classed as fertilized. However, none of 49 ova were fertilized after gilts were inseminated in the oviducts with semen from boars treated with -chlorohydrin (5 mg/kg/day). When gilts were inseminated via the oviducts with neat semen containing 1 or 10 mM -chlorohydrin added in vitro, only two of 111 ova were fertilized. The antifertility action of -chlorohydrin was very rapid, since pregnancy did not result in any of 13 gilts inseminated with semen collected either 7 or 31 hr. after boars were fed -chlorohydrin. Of eight gilts inseminated with epididymal semen collected from boars previously treated with -chlorohydrin, none were pregnant.

These studies indicated that failure of sperm cell transport in the gilt was not the primary causative factor in -chlorohydrin induced infertility of boar spermatozoa. Further, it was determined that the epididymis is the site of action of -chlorohydrin. A probable mechanism for -chlorohydrin induced infertility of boar spermatozoa is discussed.

¹ Animal Physiology and Genetics Institute, Agricultural Research Center-East, ARS.

² The authors gratefully acknowledge the technical assistance of E. M. Dimen and L. L. Schulman, and thank Ayerst Laboratories Inc., 685 Third Street, New York, N. Y., for the AIMAX, PMS and HCG used in the study.

³ Reference to commercial products or commercial producers in this report does not constitute endorsement by the U.S. Department of Agriculture to the exclusion of others that may also be suitable.