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University of California, Davis 95616
Abstract
The objectives of the investigation were to determine the utilization rate of glucose-2-T in Shetland ponies and to estimate the extent of tritium recycling into newly formed glucose following a single injection of glucose-2-T. A range of 0.5 to 2.3 and 1.3 to 5.2% recycling was observed for fasted and fed groups of ponies, respectively. The low recycling percentages were not statistically significant (P>.05) from zero except for the 4- and 6-hr. means of the fasted group. Since the recycling percentages for each hourly sample post-injection were not statistically significant, glucose half-life and fractional turnover rate in the extracellular fluid can be accurately determined by the glucose-2-T single-injection method. Glucose half-lives of 88.8±4.1 and 89.5±5.0 min. and fractional turnover rates of 0.86±.0003 and 0.78± .0004% were observed for fed and fasted group of ponies, respectively.
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