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Effect of Chlorpropamide on Gravid Swine and Blood Glucose and Fructose in the Fetal Pig¹

South Dakota State University, Brookings 57006

Abstract

SEVENTY-SIX primiparous, crossbred gilts were used in a series of two experiments to determine the effects of 1,000 and 3,000 ppm chlorpropamide upon reproductive and blood criteria. The 515 fetuses collected from these gilts were used to obtain information about the effects of chlorpropamide on individual weights and blood glucose and fructose levels. Data obtained from both gilts and fetal pigs were subjected to multiple regression to study effects upon litter size, fetal weight and fetal blood glucose content.

Gestation weight gain of gilts was significantly reduced with the addition of chlorpropamide to the diet. Average litter size and percent embryo survival were not significantly affected, although there was a trend toward better embryo survival with the addition of chlorpropamide, particularly at the higher level. Maternal blood glucose and fructose levels were not significantly affected by the addition of chlorpropamide to the diet but were significantly reduced with increased gestation length.

¹ Published with the approval of the Director of the South Dakota Agricultural Experiment Station as Publication No. 1119 of the Journal Series.

² Present address: University of Wisconsin, Platteville 53818.

³ Department of Animal Science.