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Potential Uses of Prostaglandins in Control of Reproductive Cycles of Domestic Animals¹

West Virginia University, Morgantown 26406

Abstract

Prostaglandins, specifically prostaglandin F₂ (PGF₂) have been shown to be present in high concentrations in the uterine endometrium and maternal cotyledons of sheep. Levels of PGF₂ in ovine endometrium increased during the last few days of the estrous cycle or after insertion of intrauterine devices early in the cycle. Peripheral plasma PGF₂ was increased by estrogen treatment in progesterone-primed, ovariectomized ewes, but endometrial PGF₂ was decreased by progesterone alone in ovariectomized ewes.

Exogenous PGF₂ induced luteal regression in sheep with functional corpora lutea in ovaries transplanted to the neck and in cattle during days 5 through 18 of the estrous cycle or during pregnancy. Preliminary reports from several laboratories during 1972 suggest that PGF₂ is worthy of further study as an agent for control of ovulation. Data on conception rates, dose and route of administration, timing of insemination following treatment, side effects, other prostaglandins and analogues are needed in order to assess the value of prostaglandins for control of ovulation.

¹ Invitational paper presented at the 64th Annual Meeting of the American Society of Animal Science, Virginia Polytechnic Institute and State University, Blacksburg, August 1, 1972. Original research reported herein was supported in part by Hatch funds and in part by NIH Contract 69-2215. Published with the approval of the Director of the West Virginia Agricultural Experiment Station as Scientific Paper No. 1238. Prostaglandin standards were provided by Dr. John E. Pike, The Upjohn Company. Prostaglandin F₂ for injection was provided by Mr. Kazuo Sano, Ono Pharmaceutical Company, Japan.

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