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Increased Metabolic Clearance of Cortisol by Stress-Susceptible Swine

University of Wisconsin,^,2 Madison 53706

Abstract

The metabolic clearance rate (MCR) and turnover rate of cortisol was estimated in each of three normal and three stress-susceptible swine. Tritium-labeled cortisol was infused continuously until the level of labeled cortisol in plasma was stable. Labeled cortisol was removed from the blood of stress-susceptible pigs at approximately five times the rate of normal pigs (P<.001). Similarly, the turnover rate of cortisol was significantly elevated in stress-susceptible swine (P<.001). The results indicate that stress-susceptible swine have an increased rate of cortisol utilization and production instead of an adrenal insufficiency as has been suggested in the past.

¹ The authors express their appreciation to Dr. L. L. Christian of Iowa State University for making the stress-susceptible animals available.

² Research supported by the College of Agricultural and Life Sciences, University of Wisconsin, Madison, by Public Health Service No. FD-00107-13, and by a grant from the American Meat Institute Foundation. Muscle Biology Laboratory Manuscript No. 33.