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Influence of Phenoxybenzamine and Propranolol on Blood Serotonin and pH, Plasma Cortisol and M. Longissimus pH and Color in Swine¹

Iowa State University,^,3 Ames 50010

Abstract

Blood samples were collected from a catheter placed in the anterior vena cava of 18 Yorkshire x Hampshire crossbred pigs representing the high U.S.D.A. 1 grade. Blood serotonin levels were negatively and significantly correlated with blood pH and plasma cortisol levels for samples collected before the administration of propranolol and phenoxybenzamine. Also, significantly higher levels of blood serotonin were observed in a litter of stress-susceptible pigs when compared with more stress-resistant animals. Pigs treated with phenoxybenzamine had lower blood pH and serotonin levels after stress than did the controls or propranolol-treated pigs. No significant differences in postmortem M. longissimus pH or color resulted from administration of the a or ß receptor cell blocking agents.

¹ Journal Paper No. J-7235 of the Iowa Agricultural and Home Economics Experiment Station, Ames, Project No. 1697.

² The authors wish to express their appreciation to Dr. Gordon Thomson for assistance on the statistical analysis, to Smith, Kline and French Laboratories, Philadelphia, Pa. for supplying the phenoxybenzamine and to Armour Food Research Division for partial support of this study.

³ Department Animal Science.