J. Anim Sci.
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J. Anim Sci. 1973. 36:730-733.
© 1973 American Society of Animal Science
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Insulin Turnover and Irreversible Loss Rate in Horses

J. E. Madigan1 and J. W. Evans2

University of California,,3 Davis 95616

Abstract

The half-life of insulin in the horse has been determined by several methods. Based upon glucose infusion data, the equine pancreas is slow to respond to a decline in plasma glucose concentration compared with humans. The irreversible loss rate of insulin from plasma was 1.9 to 5.6 ng/min. and the half-life was 33.3±8.4 min. as determined by a constant infusion of 131I-insulin. The half-lives for equine and porcine insulin were not different following a single injection.

Footnotes

1 Submitted as partial fulfillment of the M.S. degree.

2 The authors thank Bill Tanaka, Fred Senter and Paul Thompson for their assistance in the experiments.

3 Department of Animal Sciences.






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Copyright © 1973 by the American Society of Animal Science.