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Effects of Methallibure on Early Pregnancy in Swine¹

Ohio Agricultural Research and Development Center,⁴ Wooster 44691

Abstract

In two trials 63 gilts received 100 mg of methallibure per day for 5, 10 or 20 days beginning on day 2, 8, 16 or 24 after breeding. The gilts were slaughtered for examination 80 days or more after breeding or were permitted to farrow.

Through the 12th day of gestation reproductive function appeared to be unaffected by consumption of the estrous control compound. If feeding continued beyond day 12 and into all or a portion of the period between days 13 and 23, pregnancy was terminated. Induction of additional corpora lutea did not prevent pregnancy failure during this period. When feeding was delayed until day 24, 5 of 11 gilts maintained pregnancy. Twenty days of feeding at this period, however, altered prenatal development as evidenced by the appearance of skull abnormalities, alopecia of the scalp and varying degrees of a splay-legged condition.

¹ Approved for publication as Journal Article No. 56-72 by the Associate Director of the Ohio Agricultural Research and Development Center.

² Present address: Box 285, R.D. #3, Wheeling, West Virginia 26003.

³ Present address: U.S. Meat Animal Research Center, Clay Center, Nebraska 68933.

⁴ Department of Animal Science.