J. Anim Sci.
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J. Anim Sci. 1973. 36:535-539.
© 1973 American Society of Animal Science
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Effect of 3-Chloro-1,2-Propanediol (U-5897) on Accessory Sex Gland Secretions of Rams1

Jack L. Kreider2 and R. H. Dutt

University of Kentucky, Lexington 40506

Abstract

MATURE rams were used in two experiments to investigate the effect of daily administration of 3-chloro-1,2-propanediol (U-5897) on the accessory sex gland secretions.

In experiment 1, U-5897 was fed to rams at a daily rate of 25 mg/kg of body weight for 18 days, and ejaculates were collected every other day. Calcium, magnesium, sodium and potassium content and pH of accessory gland secretions were not significantly affected. Treatment of rams with the drug apparently did not affect the endocrine function of the testis, since no changes in fructose content of seminal plasma were found. In experiment 2 the effect of U-5897 on accessory gland secretions was investigated by sperm metabolic studies. The type of seminal fluid (from treated or untreated vasectomized rams) to which spermatozoa were exposed had no significant effect on motility or oxygen consumption, but both motility and oxygen consumption were significantly (P< .01) reduced in spermatozoa from treated rams. Motility of spermatozoa from treated rams averaged 20.3 and 26.8% compared with 50.7 and 58.7% for spermatozoa from untreated rams, when resuspended in accessory gland secretions from treated or untreated vasectomized rams, respectively. The respective mean hourly oxygen consumption by suspensions containing sperm cells from treated rams was 7.3 and 8.4 µl/108 cells compared with 16.8 and 19.2 µl/108 cells for suspensions with sperm cells from untreated rams. On the basis of the results of these studies it is apparent that the detrimental effect of U-5897 on ram sperm cell metabolism is not mediated through changes in the composition of accessory gland secretions.

Footnotes

1 Published with approval of the Director of the Kentucky Agricultural Experiment Station as Journal Article 72-5-45.

2 Present address: Department of Animal Science, Louisiana State University, Baton Rouge 70803.






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Copyright © 1973 by the American Society of Animal Science.