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Evaluation of Carboxymethylcellulose as an Injectable Carrier for Follicle Stimulating Hormone¹

South Dakota State University, Brookings 57006

Abstract

Three experiments involving 330 immature female rats were conducted to compare physiological saline (PSS) and carboxymethylcellullose (CMC) as carriers for follicle stimulating hormone (FSH) and to evaluate quantitative relationships of FSH and CMC.

One percent CMC as a carrier resulted in heavier ovarian and uterine weights than did the same quantity (0.5 mg) of FSH in PSS. This indicated an increase in the expressed biological activity of FSH. The apparent optimum ratio of FSH:CMC in the rat was 1 mg FSH to 2 ml or more of 1% CMC solution. There was also an indication that ovarian and uterine stimulation by FSH in PSS was less repeatable than FSH in CMC.

¹ Published with the approval of the Director of the South Dakota Agricultural Experiment Station as Publication No. 1089 of the Journal Series.

² Present address: Division of Animal Science, University of Wyoming, Laramie 82070.

³ Present address: Texas A&M University Agricultural Research and Extension Center, Drawer E, Overton 75684.