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Adrenal Response to Acth in the Pig^{1, 2, 3,}

University of Wisconsin, Madison 53706

Abstract

STRESS-SUSCEPTIBLE pigs, unable to maintain homeostasis on exposure to stress, show a lack of response to exogenous ACTH injection when compared to stress-resistant pigs. Dexamethasone was used to block endogenous ACTH production before injection and adrenal production of corticosteroid remained high in stress-susceptible pigs even after the blocking. Endogenous ACTH levels also remained high in stress-susceptible pigs after dexamethasone blocking. However, once ACTH is injected into stress-susceptible animals, the adrenal response is significantly lower than stress-resistant animals and is apparently not sufficient to maintain homeostasis.

¹ Research supported by the College of Agricultural and Life Sciences, University of Wisconsin, Madison, by the Public Health Service Grant No. FD00107-13 and by a grant from the American Meat Institute Foundation.

² Muscle Biology Laboratory Manuscript No. 29.

³ We thank Dr. L. Christian, Iowa State University for providing us with some of the stress-susceptible pigs used in this study.

⁴ Campbell Institute for Food Research, Camden, New Jersey.