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Effect of Added Dietary Levels of Copper Sulfate and an Antibiotic on Performance and Certain Blood Constituents of Calves^{1, 2,}

North Carolina State University at Raleigh 27607

Abstract

TWO 98-day experiments were conducted to determine the effect of added dietary levels of copper sulfate and an antibiotic on performance, blood constituents and liver copper levels of young growing calves. In both experiments four levels of copper and two levels of chlortetracycline were compared in a 2 x 4 factorial arrangement. Added dietary copper levels of 0, 125, 250 and 500 ppm were fed in Experiment I and 0, 300, 600 and 900 ppm in Experiment II. Each of the copper levels was fed with and without 22 mg chlortetracycline/kg feed.

Results of Experiment I and II indicated a significant (P<.05) increase in average daily gain due to chlortetracycline. Copper increased average daily gain significantly (P<.05) only in Experiment II. Also present in Experiment II was a significant (P<.05) interaction between chlortetracycline and copper in that copper levels gave no additional response over that observed from chlortetracycline. Carcass gain and percent shrink showed a significant (P<.05) increase due to added copper in Experiment II but not in Experiment I. In both experiments liver copper levels indicated a highly significant (P<.01) increase due to copper levels fed. Serum calcium levels in Experiment II were significantly (P<.05) decreased in calves receiving chlortetracycline. Other blood constituents in both experiments indicated no changes due to treatments. Rumen VFA analyses obtained at the end of Experiment II showed no response to treatments.

¹ Paper No. 3728 of the Journal Series of the North Carolina State University Agricultural Experiment Station, Raleigh. The use of trade names in this publication does not imply endorsement by the North Carolina Agricultural Experiment Station of the products named, nor criticism of similar ones not mentioned.

² Acknowledgment is given to The American Cyanamid Company, Princeton, New Jersey, for supplying the chlortetracycline.

³ Present address: Department of Animal Science, Virginia Polytechnic Institute and State University, Blacksburg 24061.

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