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Influence of Manganese Intake on Metabolism of Manganese and Other Minerals in Sheep^1/

University of Florida^,4, Gainesville, Florida 32601

Abstract

SIXTEEN wether lambs were used in a 2x2 factorial arrangement of treatments to study the metabolism of manganese. One hundred microcuries of ⁵⁴Mn as MnCl₂, were administered either orally or intravenously to lambs fed a basal (30 ppm manganese), or basal diet plus 4,000 ppm supplemental manganese. A 21-day fecal and urinary collection period followed the dosing with radioactive manganese. After an additional 35 days, the lambs were dosed again in a similar manner with ⁵⁴Mn. Following this dosing, blood samples were taken at intervals for 96 hr., after which all animals were killed and tissues removed for analysis. Absorption of ⁵⁴Mn was low and excretion of both stable manganese and ⁵⁴Mn was almost exclusively by way of the feces regardless of dietary manganese level or pathway of isotope administration. Low dietary manganese and intravenous administration of ⁵⁴Mn resulted in the greatest tissue retention of radioactivity. Lambs receiving low dietary manganese retained more ⁵⁴Mn in tissues than did lambs fed supplemental manganese. Tissue and plasma levels of stable manganese were higher in lambs fed the manganese-supplemented diet. High dietary manganese resulted in decreased concentrations of tissue iron and zinc.

¹ Florida Agricultural Experiment Stations, Journal Series No. 4423.

² Present address: DeKalb Feeds Division, W R. Grace and Co., DeKalb, Illinois.

³ The authors wish to thank International Minerals and Chemical Corporation, Skokie, Illinois and the Center for Tropical Agriculture, University of Florida for funds in support of this study; Charles Pfizer Company, Terre Haute, Indiana for providing vitamins A and D; and Monsanto Chemical Company, St. Louis, Missouri for supplying Santoquin. The technical assistance of Sarah M. Miller and W. G. Hillis is acknowledged.

⁴ Department of Animal Science and Department of Radiology.

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