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Effects of Fasting and Diet on Enzyme Profiles in Ovine Liver and Adipose Tissue^{1, 2,}

The Pennsylvania State University, University Park, Pa. 16802

Abstract

SIXTY wethers were used in a fasted and refeeding schedule to determine enzyme adaptations important in the long term control of metabolite flux through pathways of gluconeogenesis and lipogenesis. After a 30% reduction in empty body weight; liver glucose-6-phosphatase was reduced and after refeeding a concentrate ration, it was increased 2.5 fold. In general, when sheep were refed a concentrate ration, enzyme adaptations in both liver and adipose tissues were more dramatic than when refed hay. Enzymes normally associated with high rates of lipogenesis were elevated in adipose tissue of sheep receiving the concentrate ration. Long term adaptations to fasting in ruminants are characterized by a decrease in gluconeogenic and lipogenic enzymes. The type of diet refed has a profound influence on the enzyme profile of liver and adipose tissues.

¹ Approved for publication by the Director, Pennsylvania Agricultural Experiment Station; Paper No. 4214 of the Journal Series; authorized for publication on May 16, 1972.

² The authors gratefully acknowledge the technical assistance of M. C. Rugh and C. Rosenberger.