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Connective Tissue Metabolism in Swine. III. The Influence of Methallibure on Connective Tissue Development in Fetal Swine¹

University of Guelph,^,3 Guelph, Ontario, Canada

Abstract

THE influence of the administration of methallibure to gravid sows between the 29th and 50th day or the 39th and 60th day of gestation on the levels of collagen, mucopolysaccharide, calcium and phosphorus in skin, aorta, cranial bones, humerus, ulna, radius and metacarpals of fetal pigs at term was studied. Methallibure treatment resulted in increased levels of collagen and decreased concentrations of mucopolysaccharide in skin and aorta. There was a significantly increased concentration of calcium in the skin of pigs from sows which had received methallibure between the 29th and 50th day of gestation. The influence of methallibure treatment on bones was unique for each bone. The shaft of the humerus and the entire radius and ulna showed increased levels of collagen and calcium and decreased amounts of mucopolysaccharide. The metacarpals and the epiphyses of the humerus showed only minimal response to methallibure treatment. The principal changes found in the cranial bones were increased calcium levels and decreased mucopolysaccharide concentrations in bones from both groups which received metallibure. The observations were explained in terms of a differential effect of methallibure on the cells which synthesize mucopolysaccharide and collagen in bones and soft tissues.

¹ This study was supported by grants from the Ontario Department of Agriculture and Food and the National Research Council of Canada (5933A). The methallibure used was a generous gift of Ayerst Laboratories Ltd., Montreal, P. Q.

² Present Address: Societe d'Assistance Technique, Produits Nestlé, S. A., Vaud, Switzerland.

³ Department of Animal and Poultry Science.