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ACTH, Corticoids and Luteal Function in Heifers¹

Iowa State University,² Ames, Iowa 50010

Abstract

INTRAMUSCULAR injection of 100 Units ACTH at 0800 hr. on days 1 to 8 of the estrous cycle in six heifers significantly reduced progesterone concentration (35.6 vs. 67.2 µg/g) and total progesterone content (214.3 vs. 333.2 µg) of CL collected at day 11 when compared to saline injected controls. The ACTH treated animals had significantly increased plasma progesterone levels on day 1 to 5 of the cycle and significantly decreased plasma progesterone levels on days 8 to 10 of the cycle. Plasma corticoid levels were significantly increased during days 1 to 8 of the cycle by the ACTH treatment. Treatment of five ovariectomized heifers with 100 Units ACTH (5 days) and saline (5 days) resulted in elevated plasma progesterone levels on the ACTH treatment days (1.18 vs. 0.09 ng/ml 1 hr. post treatment). The source of this increase in progesterone is probably the adrenal cortex. Treatment of five heifers with flumethasone (5 mg/day on days 1 to 8 of the cycle) resulted in no significant changes in luteal tissue progesterone concentration.

¹ This research was performed under Contract 69-2213, Center for Population Research, NICHD.

² Veterinary Medical Research Institute.