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Pituitary Gonadotropin Levels, Endocrine Gland and Reproductive Organ Weights of Gilts Fed a Dithiocarbamoylhydrazine (ICI 33828)^{1, 2, 3,}

University of Wisconsin, Madison 53706

Abstract

The experiment was designed to test the effects of feeding gilts various levels of ICI 33828 for 16 days beginning on day 3, 13 or 18 of the estrous cycle. On the last day of feeding or on day 3 or 25 of gestation following withdrawal of the compound, the uterus, ovaries and various endocrine glands were weighed and the anterior pituitary glands were stored for measurement of FSH and LH.

Gilts slaughtered on the last day of ICI 33828 feeding had heavier (P<.05) adrenals if feeding began on day 18 as compared with those stated on day 3 or 13. The ovaries were heavier (P<.05) on the last day of feeding when ICI 33828 feeding was started on day 3 as compared with those started on day 18.

Relative concentration of anterior pituitary FSH was the same (P>.05) for the control gilts on day 18 as it was for the gilts slaughtered on the last day of feeding when ICI 33828 feeding started on day 13 or 18, indicating that FSH release was suppressed. However, the gilts fed ICI 33828 commencing on day 3 had a relative lower concentration of (P<.05) anterior pituitary FSH on the last day of feeding as compared with the control gilts slaughtered on day 18, indicating that synthesis of FSH was inhibited. There were no follicles >6 mm diameter or corpora lutea on the ovaries of any of the gilts slaughtered on the last day of ICI 33828 feeding, and there was a tendency for uterine weights to decline after luteal regression which supports the contention that the release of FSH was suppressed. Release of LH was suppressed in gilts fed ICI 33828 regardless of the day feeding started since relative LH concentrations were similar to (P>.05) those found in the control gilts on day 13 or 18. Suppression of LH release is supported by the lack of ovulation and estrus in all of the gilts fed ICI 33828.

Of the traits studied on day 3 of gestation, only relative LH concentration was lowered (P<.005) by the 116 mg dose level when compared with 58 or 232 mg levels fed.

There were no effects (P>.05) of ICI 33828 feeding prior to mating on any traits measured at day 25 of gestation.

¹ Research supported by the College of Agricultural and Life Sciences, University of Wisconsin, Madison.

² Dithiocarbamoylhydrazine (ICI 33828) Ayerst Laboratories Incorporated, New York, New York.

³ Supported in part by funds from Tri-State Breeders Cooperative, Westby, Wisconsin; The American Meat Institute, Chicago, Illinois and Murphy Products Company, Burlington, Wisconsin.

⁴ Fellow, N.I.H. during experiment. Present address: Institute for Enzyme Research, University of Wisconsin, Madison.

⁵ Department of Meat and Animal Science, Paper No. 557.