J. Anim Sci.
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J. Anim Sci. 1972. 35:97-101.
© 1972 American Society of Animal Science
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Metabolism of 1-({alpha}-Methylallylthiocarbamoyl)-2-Methylthiocarbamoylhydrazine (Methallibure) in Cattle

P. W. Aschbacher1, V. J. Feil1 and R. G. Zaylskie2, 3,

U. S. Department of Agriculture, Fargo, North Dakota 58102

Abstract

The metabolism of 1-({alpha}-methylallylthiocarb-14C-amoyl)-2-methylthiocarbamoylhydrazine (14C methallibure) was studied in lactating cows. Recoveries of 14C in urine, feces and milk after an oral dose of 14C methallibure were 79, 14.4 and 1.5%, respectively (average of three trials). Urinary metabolites were isolated using solvent extraction and various types of chromatography. Identities of metabolites were based on matching infrared and mass spectra of metabolites with spectra of authentic compounds, thin-layer chromatography or by deductive interpretation of mass spectra. The metabolites identified and their approximate abundance (as a per cent of total 14C in urine) were methallibure, 2%; 2-methylamino-5-({alpha}-methylallylamino)-1,3,4-thiadiazole, 20–25%; 2-methylamino-5-amino-1,3,4-thiadiazole, 9–12%; 2,5-diamino-1,3,4-thiadiazole, 9–12%; 3-methylmercapto-4-methyl-5-({alpha}-methylallylamino)-1,2,4-triazole, <1%, 3-mercapto-4-methyl-5-({alpha}-methylallylamino)-1,2,4-triazole, <1%; 2-amino-5-({alpha}-methylallylamino)-1,3,4-thiadiazole, <1%. Excretion and metabolism of 14C methallibure is similar in the cow and gilt.

Footnotes

1 Animal Science Research Division, A.R.S., Metabolism and Radiation Research Laboratory, Fargo, North Dakota 58102.

2 Entomology Research Division, A.R.S., Metabolism and Radiation Research Laboratory, Fargo, North Dakota 58102.

3 Reference to a company or product name does not imply approval or recommendation of the product by the U.S. Department of Agriculture to the exclusion of others that may be suitable.






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Copyright © 1972 by the American Society of Animal Science.