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Effect of Ovariectomy on Serum Luteinizing Hormone (LH) Concentrations in the Anestrous Ewe^{1, 2, 3,}

Washington State University, ³ Pullman 99163

Abstract

Four, mature, anestrous, Columbia ewes were bilaterally ovariectomized. Serum samples collected throughout the experiment were assayed for LH by radioimmunoassay. An apparent increase in serum LH was noted postovariectomy with increasing LH concentrations being noted up to day 50 postovariectomy. Rhythmic oscillations which exhibited a mean duration of 52 min. and a standard deviation of 10.5 min. were noted when samples were collected at 15-min. intervals for 24 hr. from ewes 50 days postovariectomy. The half-life for LH as calculated from the back slope of 11 observations was 27.3±2.6 minutes. The serum LH concentrations of simultaneous collections of jugular and cavernous sinus blood from three intact ewes illustrated that the cavernous sinus serum has a higher concentration of LH, 11.3±5.7 ng/ml, compared to the jugular serum concentration of 0.27 ± 0.02 ng/ml. There were no consistent oscillations in either the jugular or cavernous sinus serum LH concentrations in the intact anestrous ewes as was noted in the ovariectomized ewes.

¹ Scientific Paper No. 3761, College of Agriculture, Washington State University. Project 1695.

² The authors wish to thank Mr. M. Stoltey for his technical assistance in conducting these studies, Dr. L. Reichert for purified ovine LH for iodination, Dr. William White for anti-ovine LH serum, and the Endocrine Study Section of the National Institutes of Health for providing the NIH-LH-S16 standard used in this study.

³ Department of Animal Sciences.

³ Department of Animal Sciences.

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