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Comparative Efficacy of the High Cis and High Trans Isomers of Diethylstilbestrol for Steers^{1, 2,}

University of Kentucky,³ Lexington 40506

Abstract

Diethylstilbestrol (DES) has been used to improve weight gain and feed efficiency of growing and finishing steers. Research at various experiment stations has shown that weight gains are generally improved about 15% and feed efficiency improved about 12% by feeding DES (Burroughs et al., 1955; Burroughs and Zmolek, 1963; Clegg and Carroll, 1957; Perry et al., 1955; Riggs, 1958). Diethylstilbestrol exists in two stereochemical configurations, cis or trans. Raun, Cooley and Smith (1970) reported that by increasing or decreasing the trans or cis isomer content of DES, its biological activity is altered depending on the trans to cis ratio present. This study was initiated to compare the effects of feeding high cis DES or high trans DES on growth, carcass characteristics and certain blood pa- rameters of finishing steers.

Ninety-six Angus steers averaging 298 kg were fed in a 140-day growth trial to study the comparative efficacy of the cis and trans isomers of diethylstilbestrol.

¹ This investigation is published with approval of the Director of the Kentucky Agricultural Experiment Station.

² Diethylstilbestrol (Stilbosol^R), Eli Lilly and Company, Indianapolis, Indiana.

³ Department of Animal Sciences.