HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Miller, W. J. Articles by Pate, F. M. Search for Related Content PubMed PubMed Citation Articles by Miller, W. J. Articles by Pate, F. M.

Distribution and Turnover Rates of Radioactive Manganese in Various Tissues after Duodenal Dosing in Holstein Calves Fed a Practical-Type Diet^{1, 2,}

University of Georgia, Athens 30601

Abstract

Male Holstein calves, fed a practical-type diet with 32 ppm Mn, were sacrified 1, 4 or 12 hr. after a single tracer ⁵⁴Mn dose was administered via duodenal catheter to study manganese metabolism. The results were compared with ⁶⁵Zn data from an earlier study. Small intestinal tissues absorb ⁵⁴Mn very rapidly and in amounts similar to ⁶⁵Zn. However, the ⁵⁴Mn release rate from intestinal tissue is much more rapid, with much of it apparently going back into the intestinal contents. The upper sections of the small intestine absorb far more ⁵⁴Mn than the lower sections. Cecum and colon had high ⁵⁴Mn concentrations. In other body tissues highest ⁵⁴Mn concentrations were observed in liver and gall bladder. The abomasal tissue accumulated a substantial amount but far less than liver and gall bladder. Very low levels were detected in kidney, heart, spleen, muscle and testicle with blood concentrations below detectability limits. Tissues, other than digestive tract components, had far lower levels of ⁵⁴Mn than observed earlier for ⁶⁵Zn. Turnover rate of ⁵⁴Mn in liver is much faster than that of ⁶⁵Zn. The data suggest that ⁵⁴Mn transport from the small intestine to the other body tissues, rather than intestinal uptake, is an important way by which the body keeps manganese concentrations much lower than zinc even though dietary intake is similar.

¹ Journal Series Paper No. 1125, University of Georgia, College of Agriculture Experiment Stations, College Station, and Institute of Comparative Medicine and College of Veterinary Medicine Paper No. 871. Supported in part by PHS Research Grant No. AM 07367-NTN from the National Institute of Arthritis and Metabolic Diseases.

² The authors are indebted to Gold Kist, Atlanta, Georgia, for feed used in raising the calves; to American Cyanamid, Princeton, New Jersey, for antibiotics; to Dawe's Laboratories, Inc., Chicago, Illinois, for vitamins; and to J. B. Jones, Agronomy Division. Cooperative Extension Service, University of Georgia, for mineral analyses of the diet.

³ Dairy Science Department.

⁴ College of Veterinary Medicine.

⁵ Animal Science Department.

⁶ Present address: Everglades Experiment Station, Belle N. Y. 10016.