J. Anim Sci.
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J. Anim Sci. 1972. 34:322-325.
© 1972 American Society of Animal Science
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Effect of Prolonged Oral Administration of Activated Charcoal and of Ronnel on the Well-Being of Sheep

H. R. Crookshank1, 2,, H. E. Smalley3 and R. D. Radeleff3

U.S. Department of Agriculture and Texas A&M University, College Station 77840

Abstract

The addition of activated charcoal of plant origin at the level of 5% of the total diet, as biweekly drench, or in combination with the organophosphate insecticide, ronnel, at the level of 1,000 ppm in the diet did not significantly affect the blood serum level or urinary excretion of total calcium, copper, iron, magnesium, inorganic phosphorus, potassium, sodium, zinc, creatinine, uric acid and urea nitrogen. In addition no changes were found in the serum alkaline phosphatase and total protein levels nor in urine pH or 24-hr. volume. While the addition of either charcoal or ronnel to the diet decreased both feed intake and feed efficiency, combining the two did not produce a further decrease. Drenching with charcoal did not affect feed intake. While animals fed charcoal in the diet showed the presence of charcoal particles in the lungs upon necropsy, there was no instance of a clinical pneumonia due to inhalation of particles. At necropsy, extensive charcoal deposits were noted in the lungs and mediastinal lymph nodes. However, no inflammatory cells or exudate were noted in any of the lungs examined.

Footnotes

1 Animal Science Research Division, A.R.S., U.S.D.A., and Departments of Biochemistry and Biophysics and of Animal Science, Texas Agricultural Experiment Station.

2 Present address: Veterinary Toxicology and Entomology Research Laboratory, Veterinary Sciences Research Division, A.R.S., U.S.D.A.

3 Veterinary Toxicology and Entomology Research Laboratory, Veterinary Sciences Research Division, A.R.S., U.S.D.A.






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Copyright © 1972 by the American Society of Animal Science.