J. Anim Sci.
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J. Anim Sci. 1972. 34:294-296.
© 1972 American Society of Animal Science
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Effects of Cis-Clomiphene on Serum LH and Prolactin Levels and on the Response to LH-RH in the Ewe1

L. Debeljuk, A. Arimura, J. K. Sandow and A. V. Schally2

Endocrine and Polypeptide Laboratories, Veterans Administration Hospital and Tulane Medical School, New Orleans, Louisiana 70140

Abstract

The effects of cis-clomiphene on the concentrations of serum LH and prolactin and on the response to LH-RH in the sheep were investigated. Treatment with cis-clomiphene tended to show partial suppression of the stimulatory effect of LH-RH on the secretion of LH. No apparent effect of cis-clomiphene on the serum concentrations of LH and prolactin could be detected.

Footnotes

1 Supported in part by USPHS research grants AM-09094 and AM-07467 and grants from Research Service VALO.

2 The authors wish to express their gratitude to Dr. A. J. Kastin for his editorial advice, to Dr. D. E. Holtkamp for sending cis-clomiphene, and to Dr. Gordon D. Niswender, Dr. H. Papkoff and Dr. T. H. Lee for the gifts of anti-ovine LH antisera, purified ovine LH and purified ovine prolactin and anti-ovine prolactin antisera, respectively.






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Copyright © 1972 by the American Society of Animal Science.