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Effects of Cyclophosphamide Dosage on Wool Retention and Regrowth¹

U.S. Department of Agriculture, Beltsville, Maryland 20705

Abstract

Mature rams and ewes treated with 15, 20 or 30 mg of cyclophosphamide (CPA) per kilogram of body weight were observed over the period after the wool loosened and could have been removed until the regrowth of wool appeared. The wool, however, was not removed, but was allowed to come off as it would. The percentage of area from which wool had been lost was estimated on the head, neck and brisket, the shoulder, the side, the hip and the belly on days 16, 21 and 28 after treatment. These areas were contiguous and covered the whole wooled surface of the sheep. Wool regrowth was scored on the shoulder on days 16, 21, 28 and 32 after treatment.

The retention of the fleece over time was greater with decreasing CPA dosage. Also, appearance and rate of regrowth increased with decreasing dosage. These results are discussed in terms of the known action of cydophosphamide and also in terms of the practical management of a chemical defleecing operation.

¹ We express our thanks to Dr. H. Leo Dickison, Bristol Laboratories, Syracuse, New York, for supplying the cyclophosphamide, and to Mr. Samuel W. Eisentrout, Sheep and Fur Animal Research Branch, Animal Science Research Division, A.R.S., Beltsville, Maryland for supervision and care of the sheep.

² Animal Science Research Division, Sheep and Fur Animal Research Branch, A.R.S.