HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by McClain, P. E. Articles by Mullins, A. M. Search for Related Content PubMed Articles by McClain, P. E. Articles by Mullins, A. M.

Effect of D-Tubocurarine Chloride and Compound 48/80 on Muscle Tenderness^{1, 2,}

Louisiana State University, Baton Rouge 70803

Abstract

The effects on in vitro muscle tenderness produced by in vivo injections of a neuromuscular blocking agent (d-tubocurarine chloride) and a histamine releasing agent (compound 48/80) were investigated. Longissimus muscles from animals sacrificed 15 min. after receiving a sublethal dose of d-tubocurarine chloride (TCC) had significantly higher shear and 24-hr. postmortem pH values (P<0.05), and lower plasma potassium levels (P<0.05) than muscles from control animals. Conversely, muscles from animals sacrificed 1, 2 and 24 hr. after TCC injections were significantly more tender than controls (P< 0.05). Plasma potassium levels and muscle pH were simliar to controls at these time periods. Longissimus muscles from animals receiving a lethal dose of TCC were also significantly (P<0.05) more tender than those from control animals. Lethal doses of compound 48/80 also resulted in increased tenderness. No change in plasma sodium or potassium levels were observed in animals receiving lethal doses of TCC or 48/80; however, the muscle pH was significantly higher in the 48/80 treated animals.

¹ Published with the approval of the Director, Louisiana State University, Agricultural Experiment Station, Baton Rouge.

² This work was supported by a contract with the U.S.D.A. and authorized by the Research and Marketing Act of 1946. The contract was supervised by the Eastern Utilization Research and Development Division of the Agricultural Research Service.

³ Present address: U.S.D.A., A.R.S., Human Nutrition Research Division. Beltsville, Maryland 20705.

⁴ Present address: University of Idaho, Moscow 83843.