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Effects of Cyclophosphamide in Rams¹

West Virginia University, Morgantown 26506 and A.R.S., U.S. Department of Agriculture, Beltsville, Maryland 20705

Abstract

Two experiments were conducted to test effects of single doses of cyclophosphamide (CPA) on semen quality and fertility in rams. Doses of 25 or 30 mg CPA/kg had no effects on semen traits or fertility. A dose of 40 mg CPA/kg body weight reduced sperm cell concentration and decreased percent motility in ejaculates taken during weeks 6 and 7 post treatment, increased percent abnormal cells during week 7 and tended to reduce fertility in rams mated to an average of nine ewes each on days 46 to 49 post treatment.

¹ Published with the approval of the Director of the West Virginia Agricultural Experiment Station as scientific Paper No. 1161.

² Division of Animal and Veterinary Sciences, West Virginia University, Morgantown.

³ Animal Sciences Research Division, A.R.S., Beltsville, Maryland 20705.

⁴ The assistance of Miss Elsie M. Harrison, Mr. John Wall, Dr. Warren F. Brannon, Mr. Edward L. Squires and Mr. James T. Stevens is gratefully acknowledged.