J. Anim Sci.
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J. Anim Sci. 1971. 33:797-798.
© 1971 American Society of Animal Science
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Tissue-Residue Depletion of Sulfathiazole in Swine

H. F. Righter, J. M. Worthington and H. D. Mercer

Food and Drug Administration,1 Beltsville, Maryland 20705

Abstract

Sulfathiazole (sodium) was administered orally to feeder pigs (43 to 53 kg) at the therapeutic level of 330 mg per kilogram of body weight per day for 3 days. Sulfonamide residue levels were determined in muscle (ham), liver, kidney, fat and urine at 12 hr. after the last dosing and at 3, 5, 7, 10 and 12 days post-treatment. Residues were depleted below the method sensitivity of 0.1 ppm in liver and kidney tissues at withdrawal day 3. Residues were well below 0.1 ppm in muscle and fat at day 5 but were above this level (0.11 and 0.13 ppm, respectively) at day 7 of withdrawal. At withdrawal day 10, no detectable levels of sulfonamide were present in any of the tissues analyzed. Detectable levels of the drug were present in urine through 10 days post-treatment.

Footnotes

1 Division of Veterinary Research, Bureau of Veterinary Medicine.






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Copyright © 1971 by the American Society of Animal Science.