J. Anim Sci.
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J. Anim Sci. 1971. 33:662-666.
© 1971 American Society of Animal Science

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Chemical Additives in Rumen Fermentations: In Vivo Effects of Two Antiprotozoal Compounds on Rumen Volatile Fatty Acids

J. J. O'Connor1, G. S. Meyers, Jr.1, D. C. Maplesden1 and G. W. Vander Noot2, 3,

CIBA Corporation,4 Three Bridges, New Jersey 08887 and Rutgers University, New Brunswick, New Jersey 08903

Abstract

The amounts and relative proportions of acetic, propionic and butyric acids in the rumen vary. According to Beeson (1965) factors affecting the acetic:propionic (A:P) ratio and molar concentration of volatile fatty acids (VFA) are: (a) roughage to concentrate ratio, (b) physical form of the feed, (c) steam heating of grain, (d) buffers, (e) salivary output, (f) kind and amount of protein, (g) frequency of feeding, (h) various fatty acids, (i) fat, and (j) balance of nutrients. In in vitro rumen fermentation experiments (O'Connor et al., 1970) two chemical compounds, bis-[3-tert-butyl-4-(3-dimethylaminopropoxy)-6-methylphenyl]-sulfide dihydrochloride (Su-14,276) and 3-{6-tert-butyl-4-(1-[5-tert-butyl-4-(3-dimethylaminopropoxy)-o-tolyl]-butyl)-m-toloxy}-N,N-dimethylpropylamine dihydrochloride (Su-15,412) narrowed the A:P ratio. A narrowing of the A:P ratio has resulted in greater production of milk (Elliot and Loosli, 1959; Coppock et al., 1964) and meat (Ensor, Shaw and Tellechea, 1959; Shaw et al., 1960). Shaw et al. (1960) concluded from their work that both rate and efficiency of body weight gain in beef cattle may be influenced by controlling metabolism in the rumen.


Footnotes

1 Present address: Squibb Agricultural Research Center, Three Bridges, NJ. 08887.

2 Department of Animal Sciences, Rutgers—The State University, New Brunswick, NJ. 08903.

3 Appreciation is expressed to Mr. R. Luders and the staff of the Analytical Research and Development Division. CIBA Pharmaceutical Company for the volatile fatty acid determinations to Dr. L. Romboski of Rutgers University and Mrs. H. Sylwestrowicz of CIBA Pharmaceutical Co. for assistance in the statistical analyses.

4 Animal Health Division.







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Copyright © 1971 by the American Society of Animal Science.