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Termination of Pregnancy in Mink by Repeated Injections during the Period Preceding Implantation¹

University of Colorado,^,3 Boulder 80302

Abstract

Mink were given sequential daily injections of luteinizing hormone or saline carrier alone and the effect on the embryos noted 1 day later or on the neonates at parturition. Controls consisted of equal numbers of animals also given hormone or saline carrier but only as a single injection.

Pregnancies were terminated in 13 of the 14 animals receiving multiple injections but the same effect was not observed in the singly injected animals. These results are interpreted as responses to the stress of handling and treatment.

¹ This work was supported by N.I.H. Grant No. HD-02282.

² The author is grateful to Mr. Delbert Collicott for contributing the animals used in this study and for his help in breeding and maintaining them.

³ Department of Molecular, Cellular and Developmental Biology.

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