J. Anim Sci.
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J. Anim Sci. 1971. 33:86-95.
© 1971 American Society of Animal Science
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Early Embryo Development in the Mammal. I. Effects of Experimental Alterations during First Cell Division in the Mouse Zygote1

Donald S. Elliott2 and L. C. Ulberg

North Carolina State University, Raleigh 27607

Abstract

INFORMATION is rapidly accumulating on the metabolic mechanism involved in the growth of many species of zygotes. Yet the biology of development in the very young mammalian embryo is not very well understood. Environmental temperature is a useful experimental tool for the study of zygote development since it can be easily controlled to result in consistent effects which are similar in several different species. When pregnant females are subjected to high ambient temperature during the first few days of gestation, zygote development is altered causing an increase in embryo mortality (Ulberg, 1958; Dutt, 1960; Hafez, 1964). High ambient temperature affects reproduction in mice Ogle, 1934; Aldred, Stob and Andrews, 1961; Pennycuik, 1966, 1967). Therefore, the mouse makes an ideal biological model for the study of zygote development. Further, developmental mechanisms can be altered for the elucidation of causes for death of the subsequent embryo.

Previous work at this laboratory has indicated that if female mice are stressed by high ambient temperature during the first cell division of the zygotes, the development of some zygotes terminates early; for others, development is retarded; and still others live long enough to implant, but then die (Elliott, Burfening and Ulberg, 1968).

Footnotes

1 Paper No. 3075 of the Journal Series of the North Carolina State University Agricultural Experiment Station, Raleigh, North Carolina. Supported in part by Public Health Service Research Grant HD02923, National Institute of Child Health and Human Development.

2 Present address: Merck Sharp & Dohme, West Point, Pennsylvania.






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