J. Anim Sci.
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J. Anim Sci. 1971. 32:994-998.
© 1971 American Society of Animal Science
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Chemical Additives in Rumen Fermentations: In vitro Effects of Drugs, Inoculum Source and Substrate on Rumen Volatile Fatty Acids and Protozoa

J. J. O'Connor1, G. S. Myers, Jr.1, D. C. Maplesden1 and G. W. Vander Noot2, 3,

CIBA Corporation,4 Three Bridges 08887 and Rutgers University, New Brunswick, New Jersey 08903

Abstract

Compounds with antibacterial, antifungal or antiprotozoal activity and chloral hydrate were tested in an in vitro rumen fermentation for their effect on volatile fatty acid (VFA) production and protozoal activity. Three different diets and corresponding sources of inoculum were employed. In addition, two compounds, bis-[3-tert-butyl-4-(3-dimethylaminopropoxy)-6-methylphenyl] -sulfide dihydrochloride (Su-14,276) and 3-{6-tert-butyl-4 - (1 - [ 5 - tert - butyl - 4 - (3 -dimethylaminopropoxy-o-tolyl] - butyl )-m-toloxy }-N,N-dimethyl-propylamine dihydrochloride (Su-15,412), were studied by interchanging substrate and inoculum source.

A hay-grain substrate and inoculum from a steer fed this diet resulted in greater alteration in fermentation by the compounds as measured by VFA and protozoal activity than a mash or semi-purified substrate and inoculum (from sheep fed these diets) combination. These responses varied but were characterized for the most part by depressions in total VFA production, protozoal activity or by an increase in propionic acid values. The exception to these responses was chloral hydrate which depressed acetic acid value and the acetic:propionic acid ratio when a semi-purified substrate and inoculum were used.

Footnotes

1 Present address: Squibb Agricultural Research Center, Three Bridges, N. J. 08887.

2 Department of Animal Sciences, Rutgers—The State University, New Brunswick, N. J. 08903.

3 Appreciation is expressed to Mr. R. Luders and the staff of the Analytical Research and Development Division, CIBA Pharmaceutical Company for the volatile fatty acid determinations, and to Dr. K. K. Arora of E. R. Squibb & Sons, Inc. for the statistical analyses.

4 Animal Health Division.






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Copyright © 1971 by the American Society of Animal Science.