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Inhibition of Ovulation by Intracranial Implants of Medroxyprogesterone Acetate¹

Purdue University, Lafayette, Indiana 47907

Abstract

Medroxyprogesterone acetate, contained in the lumen of stainless steel tubing, was implanted intracranially in female guinea pigs on day 11 of the estrous cycle. Ovulation had occurred by day 19 in all controls implanted with empty tubing. Ovulation was inhibited by MAP implantation in 70% and 50%, respectively, of the animals with implants in the anterior pituitary or in the arcuate nucleus of the hypothalamus. MAP implants in other hypothalamic areas did not inhibit ovulation. MAP implants which passed through either the anterior pituitary or the arcuate nucleus and protruded from their ventral surfaces never inhibited ovulation. The present results indicate that this progestin can act directly on anterior pituitary cells to inhibit ovulation, whereas the nonsteroidal compound methallibure acted on neural structures to inhibit ovulation. MAP also may act on neural tissue of the arcuate nucleus, but the present experimental approach cannot prove or disprove such an action.

¹ Paper No. 4190, Purdue University Agricultural Experiment Station. A contribution from the Department of Animal Sciences. Supported in part by U.S. Public Health Service Grant HD 02423.

² Holder of a scholarship from The Rockfeller Foundation.

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