J. Anim Sci.
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J. Anim Sci. 1971. 32:888-890.
© 1971 American Society of Animal Science
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Response of Plasma Ca to Thyroidectomy and Calcitonin in Growing Pigs1

W. G. Pond2, E. F. Walker, Jr.2, L. Krook3 and J. R. O'Connor2, 4,

Cornell University, Ithaca, New York 14850

Abstract

Plasma Ca concentration of intact and thyroidectomized young pigs was measured before and after intravenous administration of porcine calcitonin. Calcitonin (0.2 or 0.4 mg per kilogram body weight) significantly decreased plasma Ca concentration in both intact and thyroidectomized pigs in each of three experiments. The hypercalcemic response to calcitonin was similar in both groups. There was no significant difference in plasma Ca concentration between intact and thyroidectomized pigs before calcitonin administration when pigs were not fasted (Experiments 1 and 3) but in fasted pigs (Experiment 2) thyroidectomized pigs had a significantly lower plasma Ca concentration before calcitonin administration. Calcitonin produced a hypocalcemic response in the pig similar to that observed in other species and with adequate dietary Ca lack of endogenous calcitonin (as a result of thyroidectomy) exerted little influence on plasma Ca concentration.

Footnotes

1 The authors gratefully acknowledge Cecil Brownie and Ruth Whetzel for technical assistance and Drs. H. F. Hintz and H. F. Schryver for the plasma Ca determinations. We are also indebted to Dr. J. W. Bastian, Armour Pharmaceutical Co., Kankakee, Ill., for the supply of porcine calcitonin.

2 Department of Animal Science.

3 Department of Pathology, New York State College of Veterinary Medicine.

4 Present address: 36R Main St., Washingtonville, New York.






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