J. Anim Sci.
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J. Anim Sci. 1971. 32:874-878.
© 1971 American Society of Animal Science

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Effect of Pyrantel Salts on Ascaris Suum Infection in Growing Pigs1

Dean R. Zimmerman, V. C. Speer, W. Zimmermann2 and W. P. Switzer2

Iowa Agriculture and Home Economics Experiment Station, Ames 50010,3

Abstract

Pigs were exposed to soil pens heavily contaminated with A. suum ova to evaluate the effectiveness of an ascaricide, pyrantel, against the migratory stage of A. suum. Fibrotic liver lesions were markedly reduced in pigs allowed feed ad libitum when either the tartrate or hydrochloride salt of pyrantel was added to corn-soybean meal diets at a level of 60 mg/kg (free base), or more. Lung larvae and adult intestinal ascarids also were reduced when pyrantel was included in the diet. In presence of a heavy ascarid challenge, there was no consistent improvement in pig performance when pyrantel was fed. The drug had no growth-depressing effect at a level of 60 mg/kg of diet in pigs with a low ascarid challenge. In two experiments in which protein and pyrantel level treatments were arranged factorially, weight gain and feed/gain were improved by increasing protein level. During the 35-day drug treatment period, pyrantel improved daily gain in one experiment and caused a significant protein x pyrantel interaction effect on efficiency of feed utilization in the combined experiments. The presence of pyrantel in a low protein diet (11%) improved feed/gain, but in a high protein diet (16%), pyrantel had no detectable effect. Fecal egg counts were reduced by inclusion of pyrantel in the diet.


Footnotes

1 Journal Paper No. J-6611 of the Iowa Agriculture and Home Economics Experiment Station, Ames. Project No. 1785.

2 Veterinary Medical Research Institute.

3 Department of Animal Science.







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