J. Anim Sci.
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J. Anim Sci. 1971. 32:515-524.
© 1971 American Society of Animal Science
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Metabolites of Progesterone and Estrogen in Domestic Sow Urine. I. Effect of Pregnancy1

L. A. Edgerton2 and R. E. Erb

Purdue University, Lafayette, Indiana 47907

Abstract

Two groups of crossbred gilts were bred at approximately eight months of age. Urine was collected at weekly intervals from Group I (25 gilts) from 19 to 110 days of pregnancy and from Group II (19 gilts) on 19, 26, 33, 40, 47, 75, 103 and 110 days. The purpose was to compare changes in urinary excretion of metabolites of ovarian steroids during pregnancy. As compared to Group I, Group II produced significantly more piglets per litter, excreted more estrone on days 26 and 33 and more total pregnanes (metabolites of progesterone) on days 26, 33, 40, 47 and 75. In the combined data excretion of estrone was significantly (P<.025) higher on day 26 as compared to periods from 33 through 75 days of pregnancy. Average excretion of estrone was 284, 15, 165 and 2,886 ng/mg of urinary creatinine, respectively, on days 26, 54, 75 and 110 days. On day 110, 98% of the urinary estrogen was estrone and 2% was estradiol–17 β. Excretion of pregnanes was comparatively high throughout pregnancy and ranged from 1,355±36 (54 days) to 3,244± 316 ng/mg of urinary creatinine (103 days). Though pregnane excretion decreased from 19 to 54 days the variation between gilts was high and the differences nonsignificant. By 75 days significant (P<.01) increases in excretion occurred for 5β-pregnan-3a-ol-20-one, 5β-pregnan-3a, 6a-diol-20-one and total pregnanes. Excretion of 5β-pregnan-3a, 20a-diol was significantly (P<.01) higher the last half than during the first half of pregnancy but excretion of 5a-pregnan-3β-ol-20-one did not vary significantly from 19 to 110 days of pregnancy. The excretion of 5β-pregnan-3a-ol-20-one, but not the other pregnanes, increased from 75 to 103 days of pregnancy (P<.005). Average ratios of total pregnanes to total estrogen, not significantly different between groups, increased from 26 to 54 days (13:1 vs. 71:1) and then decreased to 110 days of pregnacy (1.2:1). Estrone excretion was significantly (P<.05 to P<.01) correlated to total pregnane excretion at 19, 26, 68, 75, 82 and 110 days.

Footnotes

1 Journal Paper No. 4116 Purdue University Agricultural Experiment Station, Lafayette, Indiana 47907. A contribution from the Department of Animal Sciences.

2 Present address: Department of Dairy, Michigan State University, East Lansing 48823.






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Copyright © 1971 by the American Society of Animal Science.