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Treatment of Pregnant Ewes with Cyclophosphamide

U. S. Department of Agriculture,^,2

Abstract

Six pregnant crossbred ewes were placed in individual pens about 2 months before lambing. Two ewes were given 25 mg CPA per kilogram body weight 56 and 60 days before lambing, two were given the same level 19 and 27 days before lambing and two ewes were used as controls. All lambs were normal at birth. It was by chance that control ewes gave birth to single lambs while treated ewes gave birth to twins. Average birth weights of 5.5 kg for singles and 4.6 kg for twins were considered normal.

Treatment of pregnant ewes did not appear to affect prenatal or postnatal wool development or growth of their lambs nor did it influence the reaction of the lambs to subsequent individual treatment with CPA.

¹ The authors thank Dr. H. Leo Dickison, Bristol Laboratories, Syracuse, New York for providing the cyclophosphamide. The technical assistance of Thomas M. Murphy and Richard Bender is also gratefully acknowledged.

² Agricultural Research Service Animal Science Research Division, Beltsville, Maryland 20705.